Causes of Peripheral Artery Disease

Peripheral artery disease (PAD) is a condition characterized by narrowing or blockage of the arteries, usually in the legs, due to the buildup of fatty deposits called plaque. The primary cause of PAD is atherosclerosis, a condition where plaque accumulates in the walls of arteries, causing them to become stiff and narrow. Several factors contribute to the development of PAD:

Causes of Peripheral Artery Disease

Smoking: Tobacco use is one of the most significant risk factors for PAD. Smoking damages the lining of the arteries, leading to the buildup of plaque and narrowing of the arteries.

High Cholesterol: Elevated levels of cholesterol, particularly low-density lipoprotein (LDL) cholesterol, can contribute to the formation of plaque in the arteries, restricting blood flow.

High Blood Pressure: Hypertension can damage artery walls, making them more susceptible to plaque buildup and narrowing.

Diabetes: People with diabetes have an increased risk of developing PAD due to the damaging effects of high blood sugar levels on the blood vessels.

Obesity: Being overweight or obese increases the risk of PAD as it often accompanies other risk factors such as high cholesterol, high blood pressure, and diabetes.

Lack of Physical Activity: Sedentary lifestyle habits contribute to poor circulation and can exacerbate the progression of PAD.

Age: PAD becomes more common as people age, partly due to the natural aging process and partly due to the cumulative effects of other risk factors over time.

Family History: Individuals with a family history of PAD or cardiovascular disease are at higher risk of developing the condition themselves.

Other Medical Conditions: Certain medical conditions such as kidney disease and autoimmune disorders may increase the risk of PAD.

High Homocysteine Levels: Elevated levels of homocysteine, an amino acid in the blood, have been associated with an increased risk of PAD.

Inflammatory Conditions: Chronic inflammatory conditions such as rheumatoid arthritis may contribute to the development of PAD.


Book an appointment with Dr. Nikhil Bansal (Interventional Radiologist in Jaipur) for PAD treatment.

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